So, what do I think of a good serialized Enterprise series concept? Lets see.. (Just me throwing spaghetti at the wall for something to do.. don't read to much into it.)
So, 7 seasons, combination serialized and episodic, something like SNW but a bit more serialized.
Push back the start date from 2151 to 2154 or so.
Season 1, Somewhat the same as the first 2 seasons, the Enterprise is its first warp 5 ship, which at that speed its possible to explore in a reasonable time period, Earth still has a presence in its Earth Cargo Service, and nearby systems like Alpha Centauri with Warp 3 starfleet ships. Plans are for Enterprise to be its flagship to the stars.
With the Warp 5 break thru, other NX ships are being built as flag bearers for Earth, but they are complicated and expensive, other classes of ships like the Intrepid, Delta classes are cheaper and mass produced to build up warp 5 ship fleet to back up the Enterprise and protect ECS shipping and a general projection of power, but at first all are still being built.
So the first season is the Enterprise going out there, exploring like Seasons 1 and 2, mostly episodic, but some serial ones that push the narrative of Earth reaching out to other species in peace, and acting as mediators for old time rivalries like Vulcans and Andorians etc.
Season 2, starts the Romulan interference.
A drop here and there in the first season of someone intentionally antagonizing other species, pushing them to hate each other, keeping the quadrant fractured. But they see the humans as an upstart species, trying to bring others together. The Romulans become more aggressive in there mechanations, but go to far and are found out by the humans and other species as being the driving factor for there squabbles.
Romulans are fine with being neighbors with a bunch of weak and fractured species, easy to conqueror if they act up, but not a strong and united coalition of worlds that could threaten there Empire. Romulans try a few times to hurt the Humans as they see them as a major threat, that they could bring everyone together. ECS Ships targeted, First Starbase destroyed, all Romulans.
Finalie of season 2 is the Attack of a Romulan fleet against Earth.
Season 3, Start of the Romulan/Earth War.
Season Opener of Earth fighting of a fleet of Romulan ships, and they just do it, at the cost of alot of ships and people, millions dead on Earth ( No Xindi probe, so this is the Attack on on Earth)
Earth gears up for War, NX, Intrepid, and Delta classes are discontinued for the Comet and Daedalus classes. ( I do love the Starfleet Muesum site

) Daedalus becoming the most neumerous work horse ships, witht he comet class more of heavy assault ship. These ships are pushed out as fast as possible
Enterprise goes around the quadrant looking for support, and initially not getting any help as they see it as another "Squabble" and it is Earths problem. Not even Vulcan intervenes except for humanitarian support. So threw out this season is Enterprise going around the quadrant looking for help, and evading romulan ships, introduce Romulan Admiral Valdoore as an antaganist to Archer, with him trying to hunt down and destroy Enterprise. not much of a "WAR" season as in battles, but just the Enterprise and its travels.
S3 ends in the Kobiashi Maru Incident, with the Enterprise trying to rescue the cargo vessel from the romulans.
Season 4, Romulan/Earth War starts to get heated.
Romulans start to compel other species to fight against Earth and any other planets that join them, something like the Xindi season but with Romulans being the backers, Archer goes and finds and talks to everyone he can that is a potential ally or foe. Much to Valdoore's shagrin, it works, the more the Romulans push, the more planets that join with Earth as those planets have had Decades of abuse by the Romulans.
End of season 4, a large Romulan fleet Destroys Coridan as it is a suplyier of Dilithium, and they also attack Andoria, pushing them and more species to support Earth.
Season 5, Romulan/Earth War peaks.
Romulans decide to enter the war In Force to take out the Humans, with multipule fleets and battles, however, the past years have given time for Earth to crank out Hundreds of ships, Earth is ready as it can be, This season shows like DS9, Battles between Earth and Romulans, Introduce new ships and there crews, sometimes a whole episode with them instead of just Enterprise, and sometimes they don't make it, so some episodes are like Rogue One, no one lives at the end. Reed and Mayweather get there own ship, and have episodes with them.
Humans keep on getting pushed back, but at the end of the season a "Midway" moment happens with the help of other species and crush the Romulan fleet.
Season 6, War Ends
Romulans had a great loss, hundreds of ships were destroyed, and the Humans are pushing there advantage and heading towards Romulas. This season, they don't exactly know the location of Romulas, Archer goes and finds it, while the Terran fleet pushes through Romulan territory.
Many different crews and ships shown through the season, even through Romulan eyes.
At the end of the season Commadore Archer finds the location of Romulas and they have a war ending battle at Cheron. Romulans Sue for peace, however Archer has to reign in Earth and all the other species that want to take the fight all the way to Romulas, punishing them. Archer wins the arguement, and creates the Neutral zone. War ends.
Season 7, the Federation.
Licking the wounds of the war, Earth finds itself in a superpower role ( similar to the US after WW2) Earth has the biggest fleet in the quadrant, some more militant admirals are angry that they didn't follow through and hit Romulas, and they want to break the neutral zone, and attack the romulans, Klingons, or whomever gets in there way, Archer pacifiy's them and goes around on a good will tour of all the species to form a new coalition, to go out into space together, no one species in charge. in peace. He succeeds, and the Federation is created.
So this has Archer become a VERY big Linch pIn in History, without him the Earth might have been destroyed, lost the war, Earth becoming an Empire, Etc.
Take some episodes and introduce new characters, like a class at the Academy right before the war and show there journey from cadets to war hardened officers. Kill a few off, show some go down the bad admiral route while others go the Archer route.
so.. yeah.. long winded.. just had an idea and wanted to word dump