George Takei and Portia de Rossi are the only two America actors I can think of off the top of my head. John Barrowman also, but he mostly acts in the UK and has duel citizenship. Plus he's not very well known in the US.
This is quickly devolving into a "bash actors by calling them gay even if they're not" thread.
I'm surprised no one has mentioned Ian McKellen yet.
Also Alan Cumming and John Glover.
Kevin Spacey. Not sure if he's openly gay though.
Ellen DeGeneres, Neil Patrick Harris, Rosie O'Donnell...that's all I can think of right now.
Jane Lynch
Speaking of actors who have passed on, Rock Hudson. Speaking of actors who are alive at present, I don't know. Ian McKellan is certainly the most famous openly gay British actor, but that violates your bit asking about Americans.
This is quickly devolving into a "bash actors by calling them gay even if they're not" thread.
I was going to say that.Neil Patrick Harris?
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