Yes, in the sense that they can never go back to the tone and style of the Berman-era series as follow-ons from this series.
That doesn't mean that the representation we're getting of Picard's world in Picard doesn't work, but to see events at the time of "Encounter At Farpoint" as part of a future Trek series would probably demand an aesthetic at least as modern as Picard rather than replicating the 1987 look and feel. I can imagine them recreating one scene or location from that era as a part of a current series, in very much the same way the TOS Enterprise bridge is made to appear in "Relics;" that would be a judgement at that time by the producers.
I can't overstate my impression that this series changes the style and vision of Star Trek, forever - except in the unlikely event that it tanks early and disastrously. Ain't gonna happen, IMO, no matter how many time the goobers at "Midnight's Edge" lie to their credulous, enraged followers.