Right, I think it's time for me to avoid this thread until my copy arrives, hopefully on Friday...
In this thread, you should be safe. There was a consensus a couple days ago to keep this thread spoiler-free, which is why I've kept my posts about my play experience as free of specific details as possible (using a vague phrase like "an old friend," for example).
13 hours in and I think I've run into my first broken quest. Bleh.
If it involves not being able to speak to someone after being told to go to them, save your game, then load that same save. That situation has happened to me, and doing so allowed me to talk to the NPC after loading.