So, follow me on this.
Years before the beginning of the series House is in a relationship with a constitutional lawyer named Stacy. House suffers a crippling pain in his leg and after some time in-and-out of the hospital it's discovered a blood-clot in his leg has choked off oxygen supply to the muscle and he may need to have his leg amputated, he fights to keep the leg and in the end has himself put into a coma to "sleep through" the pain while his leg tries to heal in the wake of removing the blockage.
While in the coma Stacy, acting as his medical proxy, elects to Have house's leg muscle partly removed in order to potentially save his life while also keeping his leg (be it with reduced mobility and life-long pain.) When House recovers from the coma we're not given much information on how he reacts to the news but we know that it strained the relationship between him and Stacy and the two eventually part.
It should be noted that House's mannerisms and attitude has been described as not being too different "back then" than it is "now" (or at least during the first part of the series) aside from him now being a touch more irritable due to narcotic use.
During the second season of the series Stacy is working as the hospital's lawyer and finds herself in a love-struggle with House as he tries to woo her back in his own ways. For the most part House behaves as a "normal" person, trying to woo Stacy mostly by making her relationship with her husband show the cracks following her husband's own surgeries. In the end House rejects Stacy when she says she's willing to leave her husband and be with House, House "punishes" himself for the loss of Stacy in a manner of ways but none too extreme. In fact the only "extreme" thing he does is give himself a migraine in the process of trying to dis-credit a med school rival's new anti-migraine medication.
Flash forward to "today" where House enters a relationship with his boss and a woman he has had a relationship with since medical school, the two eventually break-up and to "cope" House:
Empties out his bank-account and spends a week sleeping with various hookers culminating into him jumping off a hotel balcony into a pool.
Marries a mail-order bride to give her a Green-Card and himself a live-in masseuse for his leg.
Relapses back onto Vicodin after a year of staying clean. (House says the pain has "returned to unbearable" but we're give no indication this "happened" unlike the last time the leg-pain returned following a treatment. It is possible he's using the drug as a coping mechanism to being dumped.)
House rents a monster truck a drives around the public streets of New Jersey.
In the anger over his former-love having move on he crashes his fucking car into House and then skips the state/country!
Tell me how his reaction to his relationship with Stacy and it's problems at all flows into how he is reacting to his break-up with Cuddy?
It doesn't flow, add up, or seem consistent with the character. This season I actually thought started off decently and was pretty good until the Huddy thing broke up and House acted like an actual lunatic culminating into what happens last night.
House, in the past, was just an eccentric jerk/genius now I'm not sure what he is. A sociopath? A psychopath? What? What is this? House used to be a fascinating and interesting character mostly in how he in interacted with people, patients, and practiced medicine. Mostly in his ways of solving puzzles and treating his patients. Now? I've no idea why I am supposed to like him and I think the show writers/creators either forgot or did not know why people liked him.